Published in
Association for Research in Vision and Ophthalmology, Investigative Ophthalmology & Visual Science, 12(53), p. 7608
Links
- ORCID
- Association for Research in Vision and Ophthalmology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
Tools
Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy
Journal article published in 2012 by
Billy X. Pan,
Fred N. Ross-Cisneros,
Valerio Carelli 
,
Kelly S. Rue,
Solange R. Salomao,
Milton N. Moraes-Filho,
Milton N. Moraes,
Adriana Berezovsky,
Rubens Belfort,
Alfredo A. Sadun
,
Kelly S. Rue,
Solange R. Salomao,
Milton N. Moraes-Filho,
Milton N. Moraes,
Adriana Berezovsky,
Rubens Belfort,
Alfredo A. Sadun
This paper is made freely available by the publisher.
Full text: Download
Postprint:
archiving forbidden
Data provided by 
Abstract
The histopathologic changes seen in the optic nerves of Leber's hereditary optic neuropathy patients follow a precise pattern of degeneration. A novel mathematical model, the nerve fiber layer stress index, is able to accurately predict this order of axonal involvement in this disease.