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Cell Press, Molecular Cell, 6(35), p. 735-736, 2009

DOI: 10.1016/j.molcel.2009.09.012

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Destruction of RhoA CULtivates actin

Journal article published in 2009 by Shuangding Wu, Dieter A. Wolf ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3BACURD targets the RhoA GTPase for degradation thereby maintaining actin cytoskeleton integrity.