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BioMed Central, Malaria Journal, 1(11), 2012

DOI: 10.1186/1475-2875-11-136

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Imported Plasmodium falciparum malaria in HIV-infected patients: a report of two cases

Journal article published in 2012 by Silvia García-Bujalance, Carolina Navarro-San Francisco ORCID, José Miguel Rubio, José Ramón Arribas, Avelino G. Gutierrez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

As HIV becomes a chronic infection, an increasing number of HIV-infected patients are travelling to malaria-endemic areas. Association of malaria with HIV/AIDS can be clinically severe. Severe falciparum malaria is a medical emergency that is associated with a high mortality, even when treated in an Intensive Care Unit. This article describes two cases of HIV-positive patients, who returned from malaria-endemic areas and presented a parasitaemia > 5% of erythrocytes and clinical signs of severe falciparum malaria, both with > 350 CD4 cell count/μl, absence of chemoprophylaxis and successful response. Factors like drug interactions and the possible implication of anti-malarial therapy bioavailability are all especially interesting in HIV-malaria co-infections.