Published in
American Society of Hematology, Blood, 10(126), p. 1214-1223, 2015
DOI: 10.1182/blood-2015-05-647172
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Disease evolution and outcomes in familial AML with germline CEBPA mutations
Journal article published in 2015 by
Kiran Tawana,
Jun Wang,
Aline Renneville 
,
C. Bodor ,
Csaba Bödör,
Robert Hills,
Chey Loveday,
Aleksandar Savic,
Frederik W. Van Delft,
Jennifer Treleaven,
Panayiotis Georgiades,
Elizabeth Uglow,
Norio Asou,
Naokuni Uike,
Maruša Debeljak
and other authors.
,
C. Bodor ,
Csaba Bödör,
Robert Hills,
Chey Loveday,
Aleksandar Savic,
Frederik W. Van Delft,
Jennifer Treleaven,
Panayiotis Georgiades,
Elizabeth Uglow,
Norio Asou,
Naokuni Uike,
Maruša Debeljak
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Germ-line CEBPA mutations are highly penetrant, causing early-onset de novo AML associated with favorable survival outcomes. Familial CEBPA-mutated AML displays a unique model of disease progression, with recurrence caused by novel, independent leukemic episodes.