Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS ONE, 7(8), p. e69050, 2013

DOI: 10.1371/journal.pone.0069050

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Activation of AMPK Inhibits Cholera Toxin Stimulated Chloride Secretion in Human and Murine Intestine

Journal article published in 2013 by Ailín C. Rogers, Lisa Huetter, Nadia Hoekstra, Danielle Collins, Anne Collaco, Alan W. Baird ORCID, Desmond C. Winter, Nadia Ameen, John P. Geibel, Sascha Kopic
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Increased intestinal chloride secretion through chloride channels, such as the cystic fibrosis transmembrane conductance regulator (CFTR), is one of the major molecular mechanisms underlying enterotoxigenic diarrhea. It has been demonstrated in the past that the intracellular energy sensing kinase, the AMP-activated protein kinase (AMPK), can inhibit CFTR opening. We hypothesized that pharmacological activation of AMPK can abrogate the increased chloride flux through CFTR occurring during cholera toxin (CTX) mediated diarrhea.