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Elsevier, Microbes and Infection, 12-13(13), p. 1002-1005, 2011

DOI: 10.1016/j.micinf.2011.06.002

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Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

Journal article published in 2011 by Adaliene Versiani Matos Ferreira ORCID, Adaliene Versiani Matos Ferreira, Marcela Segatto ORCID, Zélia Menezes, Andréa Mara Macedo, Cláudio Gelape, Luciana de Oliveira Andrade, Fnu Nagajyothi, Philipp E. Scherer, Mauro Martins Teixeira, Herbert B. Tanowitz
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.