The purpose of this prospective study was to perform the Brazilian Voice-Related Quality of Life (V-RQOL) version and to check its psychometric measurement properties and the relationship between vocal self-assessment and the instrument's scores. The translation and validation were performed following the guidelines of the Scientific Advisory Committee of Medical Outcomes Trust. The instrument was administered to 234 patients, 114 with vocal complaints, and 120 without vocal complaints. The instrument was submitted to validation, reliability, reproducibility, and responsiveness evaluation. Results showed that internal consistency was demonstrated with high coefficient values (P<0.001) and a statistically acceptable level of reliability (functioning 0.700; social-emotional 0.070; and total 0.108). Pre- and posttreatment results showed a significant responsiveness (Functioning 0.026; Social-Emotional 0.006; and Total 0.008). The study concluded that the Brazilian version of the V-RQOL is valid, reliable, and responsive to change and it can play an important role in the dysphonic patient's voice evaluation.