INTRODUCTION AND OBJECTIVES Purpose of the study is to assess through generic and IONB-specific questionnaires HRQoL in BCa patients who received RC with IONB reconstruction. METHODS we performed a multicenter, cross-sectional analysis of 171 RC-IONB patients. Patients completed the following questionnaires: the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB–Patient Reported Outcome (IONB –PRO) questionnaire. Linear/Logistic regression models tested the association between clinic-pathological variables and HRQOL domain scores and the presence of independent predictors of local recurrence and urinary incontinence. RESULTS Mean age was 60.04 and 156/171 (91.2%) were male patients. Mean follow-up period was 51.72 months. Most frequently reported concomitant medical conditions were: grade I renal impairment, grade I cardiac insufficiency, hypertension. Increasing age (p