AbstractRecent experiments on nanoscale materials, including nanowires, nanopillars, nanoparticles, nanolayers, and nanocrystals, have revealed a host of “ultra-strength” phenomena, defined by stresses in the material generally rising up to a significant fraction of the ideal strength—the highest achievable strength of a defect-free crystal. This article presents an overview of the strength-controlling deformation mechanisms and related mechanics models in ultra-strength nanoscale materials. The critical role of the activation volume is highlighted in understanding the deformation mechanisms, as well as the size, temperature, and strain rate dependence of ultra strength.