Various nanoplasmonic devices were fabricated using top-down method such as electron beam lithography, electroplating and focused ion beam techniques. These substrates were investigated after depositing the molecules from dye to protein, using chemisorptions techniques. Theoretical simulations were also performed on these model nanostructures in order to understand the electrical field distribution. Furthermore, the future prospects of these nanostructures were also mentioned in this report. Various nanoplasmonic devices can be fabricated using top-down methods such as electron beam lithography, electroplating and focused ion beam techniques. The substrates can be investigated after depositing the molecules from the dye to the protein, using chemisorptions techniques. Theoretical simulations are presented on these model nanostructures in order to understand the electrical field distribution.