Published in
Royal Society of Chemistry, RSC Advances, 9(5), p. 6265-6270, 2015
DOI: 10.1039/c4ra13570a
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Box-Behnken designed adsorption based elution - Unique separation process for commercially important acetyl shikonin from Arnebia nobilis
Journal article published in 2014 by
Shankar Subramaniam,
Anbumathi Palanisamy,
Aravind Sivasubramanian 
This paper is made freely available by the publisher.
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Abstract
Acetyl shikonin (AS), a pharmaceutically and commercially important compound, is a minor constituent in the industrial crop Arnebia nobilis. A Box–Behnken optimized, robust separation technique for AS was established by an adsorption based elution method. Optimized yields depict an increase of 78.9% total recovery of AS (97.8% pure), compared to conventional chromatography.