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American Chemical Society, ACS Medicinal Chemistry Letters, 2(3), p. 165-169, 2012

DOI: 10.1021/ml2003058

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Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

Journal article published in 2012 by Huayun Deng, Haibei Hu, Shizhang Ling ORCID, Ann M. Ferrie, Ye Fang
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.Keywords: GPR35; natural phenols; ellagic acid; biased agonism