Pyrrylphenylethanones Related to Cathinone and Lefetamine: Synthesis and Pharmacological Activities
Journal article published in 1992 by
Silvio Massa,
Roberto Di Santo,
Roberto Di Santo 
,
Antonello Mai,
Marino Artico,
Gian Carlo Pantaleoni,
Gian Carlo Pantaleoni,
Raffaele Giorgi,
Maria Francesca Coppolino
,
Antonello Mai,
Marino Artico,
Gian Carlo Pantaleoni,
Gian Carlo Pantaleoni,
Raffaele Giorgi,
Maria Francesca Coppolino
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Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.