Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 20(8), p. 2931-2936
DOI: 10.1016/s0960-894x(98)00526-5
Links
Tools
Pyrrolnitrin and Related Pyrroles Endowed with Antibacterial Activities Against Mycobacterium Tuberculosis
,
Roberto Di Santo,
Roberta Costi ,
Marino Artico,
Silvio Massa,
Giorgio Lampis,
C. Maullu,
Delia Deidda,
Raffaello Pompei
Full text: Download
Abstract
During development of nitroheterocycles with potential antimycobacterial activities we have tested against Mycobacterium tuberculosis a number of pyrroles strictly related to pyrrolnitrin, an antifungal antibiotic isolated from Streptomyces pyrrocinia. Some of the tested arylpyrrole derivatives and pyrrolnitrin have shown appreciable inhibiting activity against M. tuberculosis and M. avium. SAR studies well correlate antimycobacterial potency with the presence of halogens in the phenyl ring and a nitro group at position 3 of pyrrole.