Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 24(23), p. 6585-6587
DOI: 10.1016/j.bmcl.2013.10.060
Links
Tools
Discovery of an irreversible HCV NS5B polymerase inhibitor
Journal article published in 2013 by
Qingbei Zeng,
Anilkumar G. Nair,
G. N. Anilkumar,
Stuart B. Rosenblum,
Hsueh-Cheng Huang,
Charles A. Lesburg,
Yueheng Jiang,
Oleg Selyutin,
Tin-Yau Chan,
Frank Bennett,
Kevin X. Chen,
Srikanth Venkatraman,
Mousumi Sannigrahi,
Francisco Velazquez,
Jose S. Duca 
and other authors.
and other authors.
This paper is available in a repository.
Full text: Download
Postprint:
archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
The discovery of lead compound 2e was described. Its covalent binding to HCV NS5B polymerase enzyme was investigated by X-ray analysis. The results of distribution, metabolism and pharmacokinetics were reported. Compound 2e was demonstrated to be potent (replicon GT-1b EC50=0.003μM), highly selective, and safe in in vitro and in vivo assays.