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American Chemical Society, Journal of Medicinal Chemistry, 11(47), p. 2939-2942, 2004

DOI: 10.1021/jm031099y

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Discovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a Novel in Vivo Cannabinoid Antagonist Containing a 1,2,4-Triazole Motif

Journal article published in 2004 by Nadine Jagerovic ORCID, Laura Hernandez-Folgado, Ibon Alkorta ORCID, Pilar Goya, Miguel Navarro, Antonia Serrano ORCID, Fernando Rodriguez de Fonseca, M. Teresa Dannert, Angela Alsasua, Margarita Suardiaz, David Pascual, Maria Isabel Martín
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist.