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Molecular & Cellular Oncology, 2(2), p. e975080

DOI: 10.4161/23723556.2014.975080

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Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer

Journal article published in 2015 by Peer Bork ORCID, Murat Iskar ORCID, Vera van Noort ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Inverse gene expression profiling was recently shown to help drug repositioning. We showed that this approach works mainly for cancer and predicted novel drug candidates that may reduce metastasis in colorectal cancer. Anti-metastatic activity of our prediction, citalopram was validated in an orthotopic mouse model of metastatic colorectal cancer.