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Elsevier, Tetrahedron Letters, 24(44), p. 4459-4462, 2003

DOI: 10.1016/s0040-4039(03)01029-3

Wiley-VCH Verlag, ChemInform, 37(34), 2003

DOI: 10.1002/chin.200337125

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Pyridazines. Part 34. Retro-ene-Assisted Palladium-Catalyzed Synthesis of 4,5-Disubstituted-3(2H)-pyridazinones

Journal article published in 2003 by Eddy Sotelo, Alberto Coelho ORCID, Enrique Ravina
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The efficient one-pot bis-functionalization of the 4,5-positions of the 3-pyridazinone ring has been performed using Suzuki, Sonogashira and Stille cross-coupling reactions assisted by a retro-ene fragmentation. This route allows access in a shorter synthetic sequence to several pharmacologically useful 3(2H)-pyridazinones.