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Wiley-VCH Verlag, ChemInform, 29(34), 2003

DOI: 10.1002/chin.200329128

Elsevier, Tetrahedron, 14(59), p. 2477-2484

DOI: 10.1016/s0040-4020(03)00263-1

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Pyridazine Derivatives. Part 33. Sonogashira Approaches in the Synthesis of 5-Substituted-6-phenyl-3(2H)-pyridazinones.

Journal article published in 2003 by Alberto Coelho ORCID, Eddy Sotelo, Enrique Raviña
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed during the coupling of 1-phenyl-2-propyn-1-ol. This rearrangement afforded the E-chalcone 6 in excellent yield.