Elsevier, Tetrahedron Letters, 36(50), p. 5071-5074
DOI: 10.1016/j.tetlet.2009.06.084
Full text: Unavailable
4 pages ; International audience ; An evaluation study of various palladium supports led to the selection of charcoal as the most efficient system for the preparation of oxindoles by sequential Heck-reduction–cyclization (HRC) reactions. The in situ prepared Pd0/C was not recyclable for further cross-coupling reactions but remains still highly active for reduction processes. The sustainable chemistry described herein allows extremely simple experimental protocol under mild conditions, free of any base, ligand and additive.