Kleist, Wolfgang Proeckl, Sandra S. Drees, Markus Koehler, Klaus Djakovitch, Laurent ; This paper presents the application of zeolite (NaY) Supported Pd and Cu catalysts in animation reactions of aryl chlorides. Using 0.1 mol% Pd, good yields could be achieved in the coupling of 4-chloroacetohphenone and piperidine after 6 h at 140 C. In the second part, we demonstrate two different pathways for transition metal free amination of activated aryl chlorides and fluorides, and, respectively. non- and deactivated aryl chlorides. These reactions were performed with excellent yields in short reaction time without any transition metal catalyst under optimized reaction conditions. Activated aryl halides react smoothly using 2.1 equiv. amine without additional base whereas deactivated aryl halides require the use of a strong base ((KOBu)-Bu-t) for high conversion. DFT calculations were performed to Study the surprising influence Of substitutents at the aromatic ring oil selectivity in metal free aminations found ill this work. All rights reserved. (C) 2009 Elsevier B.V. All rights reserved.