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American Society of Nephrology, Journal of the American Society of Nephrology, 9(20), p. 1901-1905, 2009

DOI: 10.1681/asn.2008121269

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Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury

Journal article published in 2009 by Eelke M. Bos ORCID, Henri G. D. Leuvenink ORCID, Pauline M. Snijder, Niels J. Kloosterhuis, Jan-Luuk Hillebrands, Jaklien C. Leemans, Sandrine Florquin ORCID, Harry van Goor
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Abstract

Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H(2)S might have therapeutic potential to protect kidneys that suffer from hypoxia.