Much of the research in quality of life (QoL), and the majority of publications in Quality of Life Research, have employed quantitative methods. Although these methods have value in facilitating rigor and reproducibility in clinical research studies, they have a concomitant risk of losing the subtlety and distinctions experienced by patients living with health problems. The field of QoL research would benefit from an increased awareness of the value of combining qualitative and quantitative approaches and from a renewed appraisal of best practices in the use of such mixed methods. Qualitative frameworks and techniques for data collection offer a wide array of options for studying the lived experience of a disease and its treatment. Frequently used qualitative approaches to collect and analyze data and interpret results include phenomenology, grounded theory, and ethnography [1]. These approaches differ with regard to their essence. Phenomenology aims to understand the meaning of persons’ experiences. Grounded theory builds new theory and concepts from the ground up. Ethnography