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Royal Society of Chemistry, RSC Advances, 21(5), p. 15916-15922, 2015

DOI: 10.1039/c4ra16453a

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Transition metal induced switch of fluorescence and absorption response of Zn(II)porphyrin-DNA conjugate to cysteine derivatives.

Journal article published in 2015 by Jung Kyu Choi, Gevorg Sargsyan, Breiana Deon Johnson, Milan Balaz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report a supramolecular zinc(II)tettraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow to switch the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), while the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have excellent limit of detection (LODem) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nm and 13.50 nM, respectively).