Published in
Wiley, Angewandte Chemie, 45(123), p. 10874-10877
Wiley, Angewandte Chemie International Edition, 45(50), p. 10686-10689
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The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?
Journal article published in 2011 by
Marc Torrent 
,
M. Victòria Nogués,
Javier Valle ,
M. Victòria Nogués,
Ester Boix,
David Andreu
,
M. Victòria Nogués,
Javier Valle ,
M. Victòria Nogués,
Ester Boix,
David Andreu
This paper is available in a repository.
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Abstract
Action stations: Antimicrobial peptides (AMPs) can be derived from amyloid-prone regions by introduction of cationic residues at privileged positions (see picture). The design and testing of 24 de novo amyloid-derived AMPs are described, and the likelihood of evolution of amyloid-prone protein regions, devoid of antimicrobial activity, into potent antimicrobial domains is addressed.