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Wiley, Angewandte Chemie, 45(123), p. 10874-10877

DOI: 10.1002/ange.201103589

Wiley, Angewandte Chemie International Edition, 45(50), p. 10686-10689

DOI: 10.1002/anie.201103589

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The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Action stations: Antimicrobial peptides (AMPs) can be derived from amyloid-prone regions by introduction of cationic residues at privileged positions (see picture). The design and testing of 24 de novo amyloid-derived AMPs are described, and the likelihood of evolution of amyloid-prone protein regions, devoid of antimicrobial activity, into potent antimicrobial domains is addressed.