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Wiley, European Journal of Clinical Investigation, 10(33), p. 891-896, 2003

DOI: 10.1046/j.1365-2362.2003.01245.x

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Erythropoietin as an angiogenic factor

Journal article published in 2003 by D. Ribatti, A. Vacca ORCID, A. M. Roccaro, E. Crivellato, M. Presta ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal transduction pathway to perform many other functions. New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions.