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Elsevier, Psychiatry Research, 1(228), p. 174-176

DOI: 10.1016/j.psychres.2015.04.036

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Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

Journal article published in 2015 by Simon M. Rice, Miriam R. Schäfer, Claudia Klier, Nilufar Mossaheb, Nandita Vijayakumar, Günter Paul Amminger ORCID
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Abstract

A better understanding of the aberrant composition of erythrocyte membrane long chain polyunsaturated fatty acids (PUFA) for individuals at ultra-high risk (UHR) of psychosis is required for the development of new therapeutic agents. PUFA levels from an UHR sample (n=80) were compared to existing data from healthy controls (n=142). Results demonstrated significant PUFA deficits (ALA, EPA, all ω-6 PUFAs) for the UHR group. Findings provide a rationale for PUFA based interventions in emerging psychotic disorder.