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Wiley, FEBS Letters, 2(443), p. 105-108, 1999

DOI: 10.1016/s0014-5793(98)01694-9

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The intramitochondrial ATP/ADP‐ratio controls cytochrome c oxidase activity allosterically<sup>1</sup>

Journal article published in 1999 by Susanne Arnold ORCID, Bernhard Kadenbach
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Recently the signal transduction function for oxidative phosphorylation was found to be second order in ADP [Jeneson, J.A.L., Wiseman, R.W., Westerhoff, H.V. and Kushmerick, M.J. (1996) J. Biol. Chem. 271, 27995-279981, but the molecular mechanism of signal transduction remained unclear. Previously we described inhibition of cytochrome c oxidase by intramitochondrial ATP, accompanied by a change of hyperbolic into sigmoidal kinetics. The present study describes a sigmoidal relationship also between the ascorbate respiration of reconstituted cytochrome c oxidase and intraliposomal ADP concentration. Its possible role in the control of oxidative phosphorylation and cell respiration is discussed.