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Oxford University Press (OUP), The Journal of Infectious Diseases, 9(210), p. 1471-1475

DOI: 10.1093/infdis/jiu289

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Methylprednisolone Enhances the Growth of Exserohilum rostratum In Vitro, Attenuates Spontaneous Apoptosis, and Increases Mortality Rates in Immunocompetent Drosophila Flies

Journal article published in 2014 by Dimitrios Farmakiotis, Fazal Shirazi, Yanan Zhao, Peguy J. Saad, Nathaniel D. Albert, Emmanuel Roilides, Thomas J. Walsh, David S. Perlin ORCID, Dimitrios P. Kontoyiannis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.