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Springer Nature [academic journals on nature.com], Cellular & Molecular Immunology, 5(12), p. 525-532, 2015

DOI: 10.1038/cmi.2015.12

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Regulatory T cells turn pathogenic

Journal article published in 2015 by Jitao Guo, Xuyu Zhou ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Foxp3+ regulatory T (Treg) cells are considered a sub-lineage of CD4+ T cells that are protective against autoimmunity due to their essential roles in maintaining immune homeostasis and self-tolerance. However, Treg cells are unstable in vivo in terms of lineage specialization and suppressive function. These unstable Treg cells play roles in the pathogenesis of diseases, which cause safety concerns regarding human Treg cell therapy. In this review, we highlight recent findings that demonstrate the pathogenic conversion of Treg cells in different disease models.