Published in
Nature Research, Nature Immunology, 7(14), p. 696-697, 2013
DOI: 10.1038/ni.2646
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Regulation unmasked by activation
Journal article published in 2013 by
Mike Clark 
,
Anne Cooke
,
Anne Cooke
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Abstract
The glycoprotein CD52 is an important target for clinical antibodies, but its receptor and function have remained a mystery. However, it now seems that CD52 may be released in soluble form by a subpopulation of human T cells and may thereby exert an as-yet-unrecognized regulatory function via the inhibitory molecule Siglec-10.