Engineering Protein Sequence Composition for Folding Robustness Renders Efficient Noncanonical Amino acid Incorporations
Journal article published in 2010 by
Soundrarajan Nagasundarapandian,
Lars Merkel,
Nediljko Budisa 
,
Raghunathan Govindan,
Niraikulam Ayyadurai ,
Sokalingam Sriram,
Hyungdon Yun,
Sun-Gu Lee
,
Raghunathan Govindan,
Niraikulam Ayyadurai ,
Sokalingam Sriram,
Hyungdon Yun,
Sun-Gu Lee
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Abstract
Folding up: Residue-specific incorporation of noncanonical amino acids (NCAAs) often results in loss of protein function either by misfolding or aggregation (left). However, engineering the protein sequence for enhanced folding increases the mutational robustness of the protein to accommodate novel side chains and generate tailor-made proteins with new properties (right).