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Wiley, Angewandte Chemie International Edition, 12(48), p. 2188-2191, 2009

DOI: 10.1002/anie.200805613

Wiley, Angewandte Chemie, 12(121), p. 2222-2225, 2009

DOI: 10.1002/ange.200805613

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Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

Journal article published in 2009 by Anne De Cian, Marie-Paule Teulade-Fichou, Peng Yang ORCID, Jean-Louis Mergny ORCID, David Monchaud
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Lighting up: A G-quadruplex-specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G-quadruplex sensing.