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Taylor and Francis Group, OncoImmunology, 9(2), p. e25820

DOI: 10.4161/onci.25820

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Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition

Journal article published in 2013 by Alejandro López-Soto, Leticia Huergo Zapico, Andrea Acebes-Huerta, Luis Rodrigo ORCID, Segundo Gonzalez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The plasma membrane receptor natural killer group 2 member D (NKG2D) underpins a major mechanism whereby natural killer (NK) and T cells recognize malignant cells. We have recently demonstrated that the epithelial-to-mesenchymal transition, one of the first steps of metastatic dissemination, is under the control of an immunological checkpoint that relies on NKG2D-mediated immune responses.