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Elsevier, International Journal of Cardiology, 2(158), p. 199-204, 2012

DOI: 10.1016/j.ijcard.2011.01.014

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Expression of B-type natriuretic peptide forms in ischemic human hearts

Journal article published in 2011 by Raquel Cortés, Esther Roselló-Lletí, Miguel Rivera, Luis Martínez-Dolz ORCID, Antonio Salvador, Rafael Sirera, Manuel Portolés
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Background: This study sought to determine pro-B-type natriuretic peptide (proBNP), BNP, N-terminal proBNP (NT-proBNP) and GATA-4 in the same cardiac tissue, the correlation among them, and the influence of ischemic etiology on their levels. Methods: Protein levels were analyzed by Western blot techniques and mRNA expression was quantified by quantitative real-time polymerase chain reaction (RT-PCR) in a total of 33 human samples from ischemic (ICM), and control hearts. Results: Tissue protein level of proBNP is 1.5- and 12-fold higher than BNP or NT-proBNP respectively (p