Published in
Elsevier, Applied Radiation and Isotopes, (94), p. 30-34
DOI: 10.1016/j.apradiso.2014.06.016
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Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans -[ 18 F]Mefway
,
Won Gil Cho,
Tae Joo Jeon,
Chul Hyoung Lyoo ,
Yeo Wool Kang,
Soo Jin Lee,
Chul Hoon Kim,
Dong Goo Kim,
Jee Hae Kang,
Young Beom Seo,
Chi Hoon Yi,
Kyochul Lee,
Tae Hyun Choi,
Jae Yong Choi
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Abstract
The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[18F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[18F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.