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American Association for the Advancement of Science, Science, 6140(340), p. 1567-1570, 2013

DOI: 10.1126/science.1230381

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Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Journal article published in 2013 by Esther Lapuente-Brun, Raquel Moreno-Loshuertos, Rebeca Acín-Pérez, Ana Latorre-Pellicer ORCID, Carmen Colás, Eduardo Balsa, Ester Perales-Clemente, Pedro M. Quirós, Enrique Calvo, M. A. Rodriguez Hernandez, Plácido Navas, Raquel Cruz ORCID, Ángel Carracedo, A. Carracedo, Carlos López-Otín and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Respiration Refined Cells derive energy from redox reactions mediated by mitochondrial enzymes that form the electron transport chain. The enzymes can form large complexes, known as supercomplexes, whose function has been controversial. Lapuente-Brun et al. (p. 1567 ) discovered that a mouse protein, supercomplex assembly factor I (SCAFI), specifically modulates assembly of respiratory complexes into supercomplexes. Formation of the supercomplexes appears to cause electrons to be processed differently, depending on the substrate from which they are derived.