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Elsevier, Advances in Immunology, p. 31-69, 2010

DOI: 10.1016/b978-0-12-381300-8.00002-2

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Innate Signaling Networks in Mucosal IgA Class Switching

Journal article published in 2010 by Alejo Chorny ORCID, Irene Puga ORCID, Andrea Cerutti
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production.