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BioMed Central, Alzheimer's Research and Therapy, 1(7), 2015

DOI: 10.1186/s13195-015-0131-4

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Association of cognitive function with glucose tolerance and trajectories of glucose tolerance over 12 years in the AusDiab study

Journal article published in 2015 by Kaarin J. Anstey, Kerry Sargent-Cox, Ranmalee Eramudugolla ORCID, Dianna J. Magliano, Jonathan E. Shaw
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Introduction We investigated the association between glucose tolerance status and trajectories of change in blood glucose, and cognitive function in adults aged 25 to 85. Methods The sample (n = 4547) was drawn from a national, population-based cohort study in Australia (AusDiab). Fasting plasma glucose (FPG), glycated haemoglobin (HbA1c) and general health were assessed at 0, 5 and 12 years. Covariates included age, education, body mass index, blood pressure and physical activity. At 12 years, participants completed assessments of memory, processing speed and verbal ability. Results Known diabetes at baseline was associated with slower processing speed at 12 years in both younger (25–59 years) and older (>60 years) age-groups. After 12 years of follow-up, adults aged