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Published in

Wiley, Journal of Biomedical Materials Research Part A, 1(80A), p. 226-233, 2007

DOI: 10.1002/jbm.a.31096

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Transfer of apatite coating from porogens to scaffolds: Uniform apatite coating within porous poly(DL-lactic-co-glycolic acid) scaffoldin vitro

Journal article published in 2007 by Jiashen Li, Audrey Beaussart ORCID, Yun Chen, Arthur F. T. Mak
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Strategies to bone tissue engineering have focused on the use of synthetic or natural degradable materials as scaffolds for cell transplantation to guide bone regeneration. Biocompatibility, biodegradability, biomechanical integrity, and osteoconductivity are important requirements for the scaffold materials. This study explored a new approach of apatite coating to enhance the osteoconductivity of a synthetic degradable poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. The new approach was developed to ensure a relatively uniform apatite coating on the interior pore surfaces deep inside a scaffold, even for a relatively thick scaffold with small pores. Apatite was first coated on the surface of paraffin spheres of the desirable sizes. The paraffin spheres were then molded to form a foam. PLGA/pyridine solution was cast into the interspaces among the paraffin spheres. After the paraffin spheres were dissolved and removed by cyclohexane, PLGA scaffold with controlled pore size, good interconnectivity and high porosity was obtained with apatite left on the pore surface uniformly throughout the whole scaffold. The scaffold and apatite coating were characterized using thermogravimetry analysis, scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffractometry.