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Elsevier, Bioorganic and Medicinal Chemistry Letters, 18(22), p. 5795-5800

DOI: 10.1016/j.bmcl.2012.07.093

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Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein - Potential novel positron emitting tomography imaging agents

Journal article published in 2012 by Harry Wadsworth, Paul A. Jones, Wai-Fung Chau, Clare Durrant, Véronique Morisson-Iveson, Joanna Passmore, Dennis O'Shea, Duncan Wynn, Imtiaz Khan, Andrew Black, Michelle Avory, William Trigg ORCID
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This paper is available in a repository.

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Abstract

A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clinical imaging agents.