A deficit in precipitation may impact greatly on soil moisture, snowpack, stream flow, groundwater, and reservoir storage. Among the several approaches available to analyze this phenomenon, one of the most applied is the analysis of dry spells. In this paper, an investigation of the spatial and temporal patterns of dry spells, in a region of southern Italy, has been carried out on a daily precipitation dataset. First, the frequency distributions of the sequences of dry days have been analyzed. Then, the regional areas most affected by dry events have been evaluated at annual and seasonal scale. Finally, the long-term trend of the dry spells has been estimated at annual and seasonal scale. Results show that the lower probabilities of long dry spells occur in the main reliefs of the region, while the highest values have been detected in the Ionian side. The spatial distribution of the mean and maximum length values of the dry spells evidenced a west-east gradient. The trend analysis mainly revealed a negative behavior in the duration of the dry spells at annual scale and a positive trend in the winter period.