Published in
BioMed Central, Journal of Translational Medicine, 1(11), p. 248
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Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women
,
Angela Guerra,
Giuseppina Folesani ,
Franca Allegri,
Silvana Pinelli,
Paolo Baroni,
Mario Pedrazzoni,
Giuseppe Lippi ,
Annalisa Terranegra,
Elena Dogliotti,
Laura Soldati,
Loris Borghi,
Tiziana Meschi
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Abstract
Background: The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females. Materials and methods: 78 female volunteers (mean age 46 +/- 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD. Results: The women with high values of ILM had significantly higher excretion of creatinine (991 +/- 194 vs 1138 +/- 191 mg/day, p = 0.001), potassium (47 +/-+/- 13 vs 60 +/- 18 mEq/day, p