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International Union of Crystallography, Acta Crystallographica Section D: Biological Crystallography, 12(69), p. 2395-2402, 2013

DOI: 10.1107/s0907444913022294

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LigSearch: a knowledge-based web server to identify likely ligands for a protein target

Journal article published in 2013 by Tjaart A. P. de Beer ORCID, Roman A. Laskowski ORCID, Mark-Eugene Duban, A. W. Edith Chan, A. W. Edith Chan, Wayne F. Anderson, Janet M. Thornton
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources.LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands.LigSearchcan be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.