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Springer Nature [academic journals on nature.com], Cell Research, 11(25), p. 1183-1184, 2015

DOI: 10.1038/cr.2015.124

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Gasdermin D: The long-awaited executioner of pyroptosis

Journal article published in 2015 by Si Ming Man ORCID, Thirumala-Devi Kanneganti ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.