Gas phase advanced oxidation, a new method for pollution control building on the photo-oxidation and particle formation chemistry occurring in the atmosphere, is introduced and characterized. The process uses ozone and UV-C light to produce in situ radicals to oxidize pollution, generating particles that are removed by a filter; ozone is removed using a MnO2 honeycomb catalyst. This combination of in situ processes removes a wide range of pollution with a comparatively low specific energy input. Two proof of concept devices have been built to test and optimize the process. The laboratory prototype is built of standard ventilation duct and can treat up to 850 m3/hr. A portable continuous flow prototype built in an aluminum flight case treats 46 m3/hr. Removal efficiencies of >95% were observed for propane, cyclohexane, benzene, isoprene, aerosol particle mass and ozone for concentrations in the range of 0.4 to 6 ppm and exposure times up to half a minute. The laboratory prototype generates an OH· concentration derived from propane reaction of (2.5±0.3)×1010 cm-3 at a specific energy input of 3 kJ/m3 and the portable device (4.6±0.4)×109 cm-3 at 10 kJ/m3. Based on these results in situ gas phase advanced oxidation is a viable control strategy for most volatile organic compounds, specifically those with an OH· reaction rate faster than ca. 5×10-13 cm3 s-1. Gas phase advanced oxidation is able to remove compounds that react with OH, and control ozone and total particulate mass. Secondary pollution including formaldehyde and ultrafine particles may be generated depending on the composition of the primary pollution.