Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

van Dam, Rob M.; van Gilst, Wiek H.; van Veldhuisen, Dirk J.; van Meurs, Joyce B. J.; van der Harst, Pim; da Silva Couto Alves, Alexessander; dummy-Author_name,; NKelly, T.; Kato, Norihiro; Wang, X.; Drong, Alexander W.; Wang, Xu; Tan, Sian-Tsung; Scott, William R.; Ahluwalia, Tarunveer S.; Loh, Marie; Bonder, Marc Jan; Chen, Peng; Dehghan, Abbas; Edwards, Todd L.; Esko, Tõnu; Go, Min Jin; Harris, Sarah E.; Zhang, Yi; Hartiala, Jaana; Kasela, Silva; Takeuchi, Fumihiko; Kasturiratne, Anuradhani; Khor, Chiea-Chuen; Kleber, Marcus E.; Li, Huaixing; Mok, Zuan Yu; Nakatochi, Masahiro; Sapari, Nur Sabrina; Saxena, Richa; Stewart, Alexandre F. R.; Zhang, Yonghong; Stolk, Lisette; Tabara, Yasuharu; Verweij, Niek; Teh, Ai Ling; Wu, Ying; Wu, Jer-Yuarn; Hopewell, Jemma C.; Aits, Imke; Da Silva Couto Alves, A.; Das, Shikta; Dorajoo, Rajkumar; Koivula, Robert W.; CHopewell, J.; Kim, Yun Kyoung; WKoivula, R.; Nguyen, Quang N.; Luan, Jianan; Lyytikäinen, Leo-Pekka; Raitakari, Olli T.; NNguyen, Q.; Pereira, Mark A.; Bryan, Molly Scannell; Postmus, Iris; TRaitakari, O.; Zhang, Weihua; Scannell Bryan, M.; Scott, Robert A.; Sorice, Rossella; Tragante, Vinicius; Traglia, Michela; White, Jon; Yamamoto, Ken; Adair, Linda S.; Ahmed, Alauddin; Campanella, Gianluca; Akiyama, Koichi; Asif, Rasheed; Aung, Tin; Barroso, Inês; Leach, Irene Mateo; Chadeau-Hyam, Marc; Bjonnes, Andrew; Braun, Timothy R.; Cai, Hui; Chang, Li-Ching; Chen, Chien-Hsiun; Afzal, Uzma; Cheng, Ching-Yu; Chong, Yap-Seng; Collins, Rory; Saleheen, Danish; Courtney, Regina; Abbott, James; Davies, Gail; Delgado, Graciela; Do, Loi D.; Doevendans, Pieter A.; Gansevoort, Ron T.; Gao, Yu-Tang; Wander, Gurpreet S.; Grammer, Tanja B.; Wahl, Simone; Grarup, Niels; Grewal, Jagvir; Lehne, Benjamin; Gu, Dongfeng; SWander, G.; Hixson, James E.; Hartikainen, Anna-Liisa; Hazen, Stanley L.; Heng, Chew-Kiat; Kelly, Tanika N.; Hixso, E. J. A.; Hofman, Albert; Zhou, Xueya; Hsu, Chris; Huang, Wei; Tn, Kelly; Husemoen, Lise L. N.; Hwang, Joo-Yeon; Ichihara, Sahoko; Igase, Michiya; He, Jiang; Isono, Masato; Kibriya, Muhammad G.; Justesen, Johanne M.; Katsuya, Tomohiro; GKibriya, M.; Kim, Young Jin; Kishimoto, Miyako; Koh, Woon-Puay; Kohara, Katsuhiko; Kumari, Meena; Kwek, Kenneth; Lee, Nanette R.; Lee, Jeannette; Liao, Jiemin; Lieb, Wolfgang; Liewald, David C. M.; Matsubara, Tatsuaki; Matsushita, Yumi; Meitinger, Thomas; Mateo Leach, I.; Mihailov, Evelin; Milani, Lili; Zheng, Wei; Zhu, Dingliang; Mills, Rebecca; Mononen, Nina; Müller-Nurasyid, Martina; Nabika, Toru; Nakashima, Eitaro; Ng, Hong Kiat; Nikus, Kjell; Nutile, Teresa; Ohkubo, Takayoshi; Ohnaka, Keizo; Parish, Sarah; Paternoster, Lavinia; Pham, Son T.; Peng, Hao; Peters, Annette; TPham, S.; Pinidiyapathirage, Mohitha J.; Wilson Tang, W. H.; Rahman, Mahfuzar; Rakugi, Hiromi; Rolandsson, Olov; Rozario, Michelle Ann; Ruggiero, Daniela; Sala, Cinzia F.; Sarju, Ralhan; Shimokawa, Kazuro; Snieder, Harold; Sparsø, Thomas; Spiering, Wilko; Im, Leach; Starr, John M.; Stott, David J.; OStram, D.; Stram, Daniel O.; Sugiyama, Takao; Szymczak, Silke; Tang, W. H. Wilson; Tong, Lin; Aw, Drong; Trompet, Stella; Turjanmaa, Väinö; Ueshima, Hirotsugu; Uitterlinden, André G.; Umemura, Satoshi; Vaarasmaki, Marja; Dam, R. M.; Van Gilst, W. H.; Van Veldhuisen, D. J.; Viikari, Jorma S.; Wang, Yiqin; Waldenberger, Melanie; Wang, Y.; Wang, Aili; Wilson, Rory; Wong, Tien-Yin; Xiang, Yong-Bing; Yamaguchi, Shuhei; Ye, Xingwang; Young, Robin D.; Wouter Jukema, J.; Young, Terri L.; Yuan, Jian-Min; Asselbergs, Folkert W.; Ciullo, Marina; Clarke, Robert; Deloukas, Panos; Franks, Paul W.; Franke, Andre; Franks, Steve; Paul, W. F.; Franks, S.; Friedlander, Yechiel; Gross, Myron D.; Guo, Zhirong; Hansen, Torben; Jarvelin, Marjo-Riitta; Jørgensen, Torben; Jukema, J. Wouter; Kähönen, Mika; Kajio, Hiroshi; Kivimaki, Mika; Bios-Consortium,; Lee, Jong-Young; Grampluscd, Cardio; Lehtimäki, Terho; Linneberg, Allan; Miki, Tetsuro; Pedersen, Oluf; St, Tan; Samani, Nilesh J.; Sørensen, Thorkild I. A.; Takayanagi, Ryoichi; Toniolo, Daniela; Study, Lifelines Cohort; Ahsan, Habibul; Allayee, Hooman; Consortium, Interact; Chen, Yuan-Tsong; Danesh, John; Deary, Ian J.; Franco, Oscar H.; Franke, Lude; THeijman, B.; Holbrook, Joanna D.; Heijman, Bastiaan T.; Isaacs, Aaron; Wr, Scott; Kim, Bong-Jo; Lin, Xu; Liu, Jianjun; März, Winfried; Metspalu, Andres; Mohlke, Karen L.; Sangher, K.; Harambir, D.; Shu, Xiao-Ou; Van Meurs, J. B. J.; Vithana, Eranga; Sanghera, Dharambir K.; Wickremasinghe, Ananda R.; Wijmenga, Cisca; Wolffenbuttel, Bruce H. W.; Yokota, Mitsuhiro; Ts, Ahluwalia; He, Jing; Vineis, Paolo; Kyrtopoulos, Soterios A.; Kleinjans, Jos C. S.; Mccarthy, Mark I.; Soong, Richie; Gieger, Christian; Scott, James; Teo, Yik-Ying; Shyong Tai, E.; Elliott, Paul; Tai, E. Shyong; Van Der Harst, P.; Kooner, Jaspal S.; Chambers, John C.; Jc, Chambers; Mj, Bonder

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Marie Loh
van Dam et al., 2015

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Nature Research, Nature Genetics, 11(47), p. 1282-1293, 2015

DOI: 10.1038/ng.3405

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@article{van Dam2015,
  abstract = {We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 x 10(-11) to 5.0 x 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 x 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.},
  author = {van Dam, Rob M. and van Gilst, Wiek H. and van Veldhuisen, Dirk J. and van Meurs, Joyce B. J. and van der Harst, Pim and da Silva Couto Alves, Alexessander and dummy-Author_name,  and NKelly, T. and Kato, Norihiro and Wang, X. and Drong, Alexander W. and Wang, Xu and Tan, Sian-Tsung and Scott, William R. and Ahluwalia, Tarunveer S. and Loh, Marie and Bonder, Marc Jan and Chen, Peng and Dehghan, Abbas and Edwards, Todd L. and Esko, Tõnu and Go, Min Jin and Harris, Sarah E. and Zhang, Yi and Hartiala, Jaana and Kasela, Silva and Takeuchi, Fumihiko and Kasturiratne, Anuradhani and Khor, Chiea-Chuen and Kleber, Marcus E. and Li, Huaixing and Mok, Zuan Yu and Nakatochi, Masahiro and Sapari, Nur Sabrina and Saxena, Richa and Stewart, Alexandre F. R. and Zhang, Yonghong and Stolk, Lisette and Tabara, Yasuharu and Verweij, Niek and Teh, Ai Ling and Wu, Ying and Wu, Jer-Yuarn and Hopewell, Jemma C. and Aits, Imke and Da Silva Couto Alves, A. and Das, Shikta and Dorajoo, Rajkumar and Koivula, Robert W. and CHopewell, J. and Kim, Yun Kyoung and WKoivula, R. and Nguyen, Quang N. and Luan, Jianan and Lyytikäinen, Leo-Pekka and Raitakari, Olli T. and NNguyen, Q. and Pereira, Mark A. and Bryan, Molly Scannell and Postmus, Iris and TRaitakari, O. and Zhang, Weihua and Scannell Bryan, M. and Scott, Robert A. and Sorice, Rossella and Tragante, Vinicius and Traglia, Michela and White, Jon and Yamamoto, Ken and Adair, Linda S. and Ahmed, Alauddin and Campanella, Gianluca and Akiyama, Koichi and Asif, Rasheed and Aung, Tin and Barroso, Inês and Leach, Irene Mateo and Chadeau-Hyam, Marc and Bjonnes, Andrew and Braun, Timothy R. and Cai, Hui and Chang, Li-Ching and Chen, Chien-Hsiun and Afzal, Uzma and Cheng, Ching-Yu and Chong, Yap-Seng and Collins, Rory and Saleheen, Danish and Courtney, Regina and Abbott, James and Davies, Gail and Delgado, Graciela and Do, Loi D. and Doevendans, Pieter A. and Gansevoort, Ron T. and Gao, Yu-Tang and Wander, Gurpreet S. and Grammer, Tanja B. and Wahl, Simone and Grarup, Niels and Grewal, Jagvir and Lehne, Benjamin and Gu, Dongfeng and SWander, G. and Hixson, James E. and Hartikainen, Anna-Liisa and Hazen, Stanley L. and Heng, Chew-Kiat and Kelly, Tanika N. and Hixso, E. J. A. and Hofman, Albert and Zhou, Xueya and Hsu, Chris and Huang, Wei and Tn, Kelly and Husemoen, Lise L. N. and Hwang, Joo-Yeon and Ichihara, Sahoko and Igase, Michiya and He, Jiang and Isono, Masato and Kibriya, Muhammad G. and Justesen, Johanne M. and Katsuya, Tomohiro and GKibriya, M. and Kim, Young Jin and Kishimoto, Miyako and Koh, Woon-Puay and Kohara, Katsuhiko and Kumari, Meena and Kwek, Kenneth and Lee, Nanette R. and Lee, Jeannette and Liao, Jiemin and Lieb, Wolfgang and Liewald, David C. M. and Matsubara, Tatsuaki and Matsushita, Yumi and Meitinger, Thomas and Mateo Leach, I. and Mihailov, Evelin and Milani, Lili and Zheng, Wei and Zhu, Dingliang and Mills, Rebecca and Mononen, Nina and Müller-Nurasyid, Martina and Nabika, Toru and Nakashima, Eitaro and Ng, Hong Kiat and Nikus, Kjell and Nutile, Teresa and Ohkubo, Takayoshi and Ohnaka, Keizo and Parish, Sarah and Paternoster, Lavinia and Pham, Son T. and Peng, Hao and Peters, Annette and TPham, S. and Pinidiyapathirage, Mohitha J. and Wilson Tang, W. H. and Rahman, Mahfuzar and Rakugi, Hiromi and Rolandsson, Olov and Rozario, Michelle Ann and Ruggiero, Daniela and Sala, Cinzia F. and Sarju, Ralhan and Shimokawa, Kazuro and Snieder, Harold and Sparsø, Thomas and Spiering, Wilko and Im, Leach and Starr, John M. and Stott, David J. and OStram, D. and Stram, Daniel O. and Sugiyama, Takao and Szymczak, Silke and Tang, W. H. Wilson and Tong, Lin and Aw, Drong and Trompet, Stella and Turjanmaa, Väinö and Ueshima, Hirotsugu and Uitterlinden, André G. and Umemura, Satoshi and Vaarasmaki, Marja and Dam, R. M. and Van Gilst, W. H. and Van Veldhuisen, D. J. and Viikari, Jorma S. and Wang, Yiqin and Waldenberger, Melanie and Wang, Y. and Wang, Aili and Wilson, Rory and Wong, Tien-Yin and Xiang, Yong-Bing and Yamaguchi, Shuhei and Ye, Xingwang and Young, Robin D. and Wouter Jukema, J. and Young, Terri L. and Yuan, Jian-Min and Asselbergs, Folkert W. and Ciullo, Marina and Clarke, Robert and Deloukas, Panos and Franks, Paul W. and Franke, Andre and Franks, Steve and Paul, W. F. and Franks, S. and Friedlander, Yechiel and Gross, Myron D. and Guo, Zhirong and Hansen, Torben and Jarvelin, Marjo-Riitta and Jørgensen, Torben and Jukema, J. Wouter and Kähönen, Mika and Kajio, Hiroshi and Kivimaki, Mika and Bios-Consortium,  and Lee, Jong-Young and Grampluscd, Cardio and Lehtimäki, Terho and Linneberg, Allan and Miki, Tetsuro and Pedersen, Oluf and St, Tan and Samani, Nilesh J. and Sørensen, Thorkild I. A. and Takayanagi, Ryoichi and Toniolo, Daniela and Study, Lifelines Cohort and Ahsan, Habibul and Allayee, Hooman and Consortium, Interact and Chen, Yuan-Tsong and Danesh, John and Deary, Ian J. and Franco, Oscar H. and Franke, Lude and THeijman, B. and Holbrook, Joanna D. and Heijman, Bastiaan T. and Isaacs, Aaron and Wr, Scott and Kim, Bong-Jo and Lin, Xu and Liu, Jianjun and März, Winfried and Metspalu, Andres and Mohlke, Karen L. and Sangher, K. and Harambir, D. and Shu, Xiao-Ou and Van Meurs, J. B. J. and Vithana, Eranga and Sanghera, Dharambir K. and Wickremasinghe, Ananda R. and Wijmenga, Cisca and Wolffenbuttel, Bruce H. W. and Yokota, Mitsuhiro and Ts, Ahluwalia and He, Jing and Vineis, Paolo and Kyrtopoulos, Soterios A. and Kleinjans, Jos C. S. and Mccarthy, Mark I. and Soong, Richie and Gieger, Christian and Scott, James and Teo, Yik-Ying and Shyong Tai, E. and Elliott, Paul and Tai, E. Shyong and Van Der Harst, P. and Kooner, Jaspal S. and Chambers, John C. and Jc, Chambers and Mj, Bonder},
  doi = {10.1038/ng.3405},
  journal = {Nature Genetics},
  month = {sep},
  pages = {1282-1293},
  title = {Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation},
  url = {http://www.nature.com/articles/ng.3405.pdf},
  volume = {47},
  year = {2015}
}

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Journal article published in 2015 by Rob M. van Dam, Wiek H. van Gilst, Dirk J. van Veldhuisen, Joyce B. J. van Meurs, Pim van der Harst, Alexessander da Silva Couto Alves, dummy-Author_name, T. NKelly, Norihiro Kato, X. Wang, Alexander W. Drong, Xu Wang, Sian-Tsung Tan, William R. Scott, Tarunveer S. Ahluwalia and other authors. Rob M. van Dam, Wiek H. van Gilst, Dirk J. van Veldhuisen, Joyce B. J. van Meurs, Pim van der Harst, Alexessander da Silva Couto Alves, dummy-Author_name, T. NKelly, Norihiro Kato, X. Wang, Alexander W. Drong, Xu Wang, Sian-Tsung Tan, William R. Scott, Tarunveer S. Ahluwalia, Marie Loh

, Marc Jan Bonder, Peng Chen, Abbas Dehghan

, Todd L. Edwards, Tõnu Esko

, Min Jin Go, Sarah E. Harris, Yi Zhang, Jaana Hartiala, Silva Kasela, Fumihiko Takeuchi

, Anuradhani Kasturiratne, Chiea-Chuen Khor, Marcus E. Kleber

, Huaixing Li, Zuan Yu Mok, Masahiro Nakatochi

, Nur Sabrina Sapari, Richa Saxena, Alexandre F. R. Stewart, Yonghong Zhang, Lisette Stolk, Yasuharu Tabara, Niek Verweij

, Ai Ling Teh, Ying Wu, Jer-Yuarn Wu, Jemma C. Hopewell, Imke Aits, A. Da Silva Couto Alves

, Shikta Das, Rajkumar Dorajoo

, Robert W. Koivula, J. CHopewell, Yun Kyoung Kim, R. WKoivula, Quang N. Nguyen, Jianan Luan, Leo-Pekka Lyytikäinen, Olli T. Raitakari, Q. NNguyen, Mark A. Pereira, Molly Scannell Bryan, Iris Postmus, O. TRaitakari, Weihua Zhang, M. Scannell Bryan, Robert A. Scott, Rossella Sorice, Vinicius Tragante, Michela Traglia, Jon White, Ken Yamamoto, Linda S. Adair, Alauddin Ahmed, Gianluca Campanella

, Koichi Akiyama

, Rasheed Asif, Tin Aung, Inês Barroso, Irene Mateo Leach, Marc Chadeau-Hyam, Andrew Bjonnes, Timothy R. Braun, Hui Cai, Li-Ching Chang, Chien-Hsiun Chen, Uzma Afzal, Ching-Yu Cheng

, Yap-Seng Chong

, Rory Collins, Danish Saleheen, Regina Courtney, James Abbott

, Gail Davies, Graciela Delgado, Loi D. Do, Pieter A. Doevendans, Ron T. Gansevoort, Yu-Tang Gao, Gurpreet S. Wander, Tanja B. Grammer, Simone Wahl, Niels Grarup, Jagvir Grewal, Benjamin Lehne, Dongfeng Gu, G. SWander, James E. Hixson, Anna-Liisa Hartikainen, Stanley L. Hazen, Chew-Kiat Heng, Tanika N. Kelly, E. J. A. Hixso, Albert Hofman, Xueya Zhou, Chris Hsu, Wei Huang, Kelly Tn, Lise L. N. Husemoen, Joo-Yeon Hwang, Sahoko Ichihara, Michiya Igase, Jiang He, Masato Isono, Muhammad G. Kibriya, Johanne M. Justesen

, Tomohiro Katsuya, M. GKibriya, Young Jin Kim, Miyako Kishimoto, Woon-Puay Koh, Katsuhiko Kohara, Meena Kumari, Kenneth Kwek, Nanette R. Lee, Jeannette Lee, Jiemin Liao, Wolfgang Lieb, David C. M. Liewald

, Tatsuaki Matsubara, Yumi Matsushita, Thomas Meitinger, I. Mateo Leach, Evelin Mihailov, Lili Milani, Wei Zheng, Dingliang Zhu, Rebecca Mills, Nina Mononen, Martina Müller-Nurasyid, Toru Nabika, Eitaro Nakashima, Hong Kiat Ng, Kjell Nikus, Teresa Nutile, Takayoshi Ohkubo, Keizo Ohnaka

, Sarah Parish, Lavinia Paternoster

, Son T. Pham, Hao Peng, Annette Peters, S. TPham, Mohitha J. Pinidiyapathirage

, W. H. Wilson Tang, Mahfuzar Rahman, Hiromi Rakugi, Olov Rolandsson, Michelle Ann Rozario, Daniela Ruggiero, Cinzia F. Sala, Ralhan Sarju, Kazuro Shimokawa, Harold Snieder, Thomas Sparsø, Wilko Spiering

, Leach Im, John M. Starr, David J. Stott, D. OStram, Daniel O. Stram

, Takao Sugiyama, Silke Szymczak, W. H. Wilson Tang, Lin Tong, Drong Aw, Stella Trompet, Väinö Turjanmaa, Hirotsugu Ueshima

, André G. Uitterlinden, Satoshi Umemura, Marja Vaarasmaki, R. M. Dam, W. H. Van Gilst, D. J. Van Veldhuisen, Jorma S. Viikari, Yiqin Wang, Melanie Waldenberger, Y. Wang, Aili Wang, Rory Wilson, Tien-Yin Wong, Yong-Bing Xiang, Shuhei Yamaguchi, Xingwang Ye

, Robin D. Young, J. Wouter Jukema, Terri L. Young, Jian-Min Yuan, Folkert W. Asselbergs

, Marina Ciullo, Robert Clarke, Panos Deloukas

, Paul W. Franks, Andre Franke, Steve Franks, W. F. Paul, S. Franks, Yechiel Friedlander, Myron D. Gross, Zhirong Guo, Torben Hansen, Marjo-Riitta Jarvelin, Torben Jørgensen, J. Wouter Jukema, Mika Kähönen, Hiroshi Kajio, Mika Kivimaki, Bios-Consortium, Jong-Young Lee

, Cardio Grampluscd, Terho Lehtimäki, Allan Linneberg

, Tetsuro Miki, Oluf Pedersen, Tan St, Nilesh J. Samani, Thorkild I. A. Sørensen, Ryoichi Takayanagi, Daniela Toniolo, Lifelines Cohort Study, Habibul Ahsan, Hooman Allayee, Interact Consortium, Yuan-Tsong Chen, John Danesh, Ian J. Deary, Oscar H. Franco, Lude Franke

, B. THeijman, Joanna D. Holbrook, Bastiaan T. Heijman, Aaron Isaacs, Scott Wr, Bong-Jo Kim, Xu Lin, Jianjun Liu, Winfried März, Andres Metspalu, Karen L. Mohlke, K. Sangher, D. Harambir, Xiao-Ou Shu, J. B. J. Van Meurs, Eranga Vithana, Dharambir K. Sanghera, Ananda R. Wickremasinghe, Cisca Wijmenga

, Bruce H. W. Wolffenbuttel, Mitsuhiro Yokota, Ahluwalia Ts, Jing He, Paolo Vineis, Soterios A. Kyrtopoulos, Jos C. S. Kleinjans, Mark I. Mccarthy, Richie Soong

, Christian Gieger

, James Scott, Yik-Ying Teo, E. Shyong Tai, Paul Elliott

, E. Shyong Tai, P. Van Der Harst, Jaspal S. Kooner, John C. Chambers, Chambers Jc, Bonder Mj

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Abstract

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 x 10(-11) to 5.0 x 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 x 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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