Published in
Wiley, FEBS Letters, 1-3(522), p. 3-5, 2002
DOI: 10.1016/s0014-5793(02)02881-8
Links
Tools
Does chloroquine really act through oxidative stress?
Journal article published in 2002 by
Diego Monti,
Nicoletta Basilico,
Silvia Parapini 
,
Erica Pasini,
Piero Olliaro,
Donatella Taramelli
,
Erica Pasini,
Piero Olliaro,
Donatella Taramelli
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO(2) and 93% N(2). Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.