Published in
Taylor and Francis Group, Cell Cycle, 7(4), p. 914-918
DOI: 10.4161/cc.4.7.1822
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TRAIL: At the center of drugable anti-tumor pathways
Journal article published in 2005 by
Nicole Clarke,
Angela Nebbioso,
Lucia Altucci,
Hinrich Gronemeyer 
This paper is made freely available by the publisher.
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Abstract
Molecular analysis, in vivo and in vitro has identified TRAIL as a central component of anti-cancer networks in the cell. More recently, TRAIL has been shown to be involved in the selective apoptosis of AML cells by histone deacetylase inhibitors (HDACi). Here we summarize findings that the TRAIL pathway is a key factor in the apoptotic action of HDACi, as well as, retinoids and retinoid-combinations.