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Wiley, British Journal of Haematology, 1(98), p. 210-212, 1997

DOI: 10.1046/j.1365-2141.1997.1692986.x

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Successive transformation of chronic myelomonocytic leukaemia into acute myeloblastic then lymphoblastic leukaemia, both with minor-bcr rearrangement

Journal article published in 1997 by Marie Michele Dautel, Sylvie Francois, Marie-Francoise Bertheas, Laurence Baranger, Jacques Gardais, Marc Boasson, Norbert Ifrah, Odile Blanchet ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report a case of chronic myelomonocytic leukaemia (CMML), which transformed first into acute myeloblastic leukaemia (AML) and then into acute lymphoblastic leukaemia (ALL). In the AML and ALL phases, chromosome analysis showed a classic Philadelphia chromosome (Ph) t(9:22)(q34:q11). Molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2 compatible with a p190(bcr/abl) breakpoint as observed in Ph-positive lymphoblastic acute leukaemia. The minor (m-bcr) rearrangement was also detected during complete remission. This observation supports a multistep pathogenesis of leukaemias, and that the p190(bcr/abl) breakpoint may influence the course of the disease.